期刊
MEDICAL GAS RESEARCH
卷 6, 期 4, 页码 232-236出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/2045-9912.196907
关键词
hyperbaric oxygen; therapy; preconditioning; brain ischemia; hemorrhage; stroke; mechanism; clinical trial
资金
- National Basic Research Program of China (973 Program) [2014CB541600]
- National Natural Science Foundation of China [81471261]
- Major Special Program of PLA in China [AWS12J004]
- China Scholarship Council [201503170091]
To date, the therapeutic methods for ischemic and hemorrhagic stroke are still limited. The lack of oxygen supply is critical for brain injury following stroke. Hyperbaric oxygen (HBO), an approach through a process in which patients breathe in 100% pure oxygen at over 101 kPa, has been shown to facilitate oxygen delivery and increase oxygen supply. Hence, HBO possesses the potentials to produce beneficial effects on stroke. Actually, accumulated basic and clinical evidences have demonstrated that HBO therapy and preconditioning could induce neuroprotective functions via different mechanisms. Nevertheless, the lack of clinical translational study limits the application of HBO. More translational studies and clinical trials are needed in the future to develop effective HBO protocols.
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