期刊
FRONTIERS IN PHYSIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2017.00996
关键词
mydriatic eye drops; phenylephrine; tropicamide; retinal vessels; peripapillary retinal vasculature; optic coherence tomography angiography; healthy volunteers
类别
资金
- New Technology Research Project, Shanghai Municipal Commission of Health and Family Planning [SHDC12014114, 2013SY058]
- National Major Scientific Equipment Program [2012YQ12008003]
- Special Scientific Research Project of Health Professions [201302015]
- Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [81020108017]
- State Key Program of the National Natural Science Foundation of China [81430007]
- Shanghai Committee of Science and Technology [13430710500, 16140901000, 15DZ1942204]
- Shanghai Natural Science Foundation [14ZR1405400]
- National Key Research and Development Plan [2017YFC0108200]
Purpose: To evaluate and compare the effect of topical mydriatic eye drops (0.5% tropicamide alone, and a 0.5% tropicamide/0.5% phenylephrine mixture) on the retinal perfusion using optic coherence tomography angiography (OCTA). Methods: The perfused vessel density in the macular and peripapillary areas of both eyes was measured in eight healthy subjects using OCTA and a split-spectrum amplitude decorrelation angiography algorithm (SSADA). Various parameters, including retinal vessel density, were obtained at baseline and again 30 min after the instillation of either the tropicamide or the tropicamide/phenylephrine mixture eye drops in the right eye. Results: Following instillation of the tropicamide/phenylephrine mixture eye drops, there was a significant reduction of vessel density in the peripapillary area (from 89.63 +/- 4.53% to 85.00 +/- 4.14%, P = 0.034), but not in the macular areas. The mean effect size in the peripapillary area was -4.63%, and was not correlated with age, sex, or baseline vessel density. There was no reduction in vessel density in the macular or peripapillary areas after instillation of 0.5% tropicamide alone, and no reduction in vessel density in the contralateral (control) eyes. Conclusion: Topical phenylephrine reduced the retinal vessel density within the peripapillary area, but not within the macular area. Therefore, studies using OCTA, especially those focusing on the peripapillary area, should take into account this effect of phenylephrine on vessel density.
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