期刊
FRONTIERS IN PHYSIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2017.00186
关键词
chronic kidney disease; hypertension; hyperbaric oxygen supplementation; renal hypoxia; systemic vascular resistance; cardiac output
类别
资金
- Dutch Kidney Foundation [KJPF1 12.029]
- Netherlands Organization for Health Research and Developmen (ZonMw, Clinical Fellowship) [40007039712461]
Renal hypoxia is thought to be an important pathophysiological factor in the progression of chronic kidney disease (CKD) and the associated hypertension. In a previous study among CKD patients, supplementation with 100% oxygen reduced sympathetic nerve activity (SNA) and lowered blood pressure (BP). We aimed to assess the underlying haemodynamic modulation and hypothesized a decreased systemic vascular resistance (SVR). To that end, 19 CKD patients were studied during 15-min intervals of increasing partial oxygen pressure (ppO(2)) from room air (0.21 ATA) to 1.0 ATA and further up to 2.4 ATA, while continuously measuring finger arterial blood pressure (Finapres). Off-line, we derived indexes of SVR, cardiac output (CO) and baroreflex sensitivity from the continuous BP recordings (Modelflow). During oxygen supplementation, systolic, and diastolic BP both increased dose dependently from 128 +/- 24 and 72 +/- 19 mmHg respectively at baseline to 141 +/- 23 (p < 0.001) and 80 +/- 21 mmHg (p < 0.001) at 1.0 ATA oxygen. Comparing baseline and 1.0 ATA oxygen, SVR increased from 1440 546 to 1745 +/- 710 dyn-s/cm(5) (p = 0.009), heart rate decreased from 60 + 8 to 58 + 6 bpm (p < 0.001) and CO from 5.0 +/- 1.3 to 4.6 +/- 1.1 Umin (p = 0.02). Baroreflex sensitivity remained unchanged (13 +/- 13 to 15 +/- 12 ms/mmHg). These blood pressure effects were absent in a negative control group of eight young healthy subjects. We conclude that oxygen supplementation in CKD patients causes a non-baroreflex mediated increased in SVR and blood pressure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据