期刊
FRONTIERS OF MATERIALS SCIENCE
卷 11, 期 2, 页码 106-119出版社
HIGHER EDUCATION PRESS
DOI: 10.1007/s11706-017-0375-y
关键词
silicate-doped; molecular assembly; biomimetic bone; bone regeneration; osteoblastic differentiation
资金
- National Natural Science Foundation of China [81461148032, 81471792, 31430029, 81601610, 31670968]
- HUST Key Innovation Team Foundation for Interdisciplinary Promotion [2016JCTD101]
- Research Fund for the Doctoral Program of Higher Education of China [20110142110034]
Bio-inspired hybrid materials that contain organic and inorganic networks interpenetration at the molecular level have been a particular focus of interest on designing novel nanoscale composites. Here we firstly synthesized a series of hybrid bone composites, silicon-hydroxyapatites/silk fibroin/collagen, based on a specific molecular assembled strategy. Results of material characterization confirmed that silicate had been successfully doped into nano-hydroxyapatite lattice. In vitro evaluation at the cellular level clearly showed that these Si-doped composites were capable of promoting the adhesion and proliferation of rat mesenchymal stem cells (rMSCs), extremely enhancing osteoblastic differentiation of rMSCs compared with silicon-free composite. More interestingly, we found there was a critical point of silicon content in the composition on regulating multiple cell behaviors. In vivo animal evaluation further demonstrated that Si-doped composites enabled to significantly improve the repair of cranial bone defect. Consequently, our current work not only suggests fabricating a potential bone repair materials by integrating element-doping and molecular assembled strategy in one system, but also paves a new way for constructing multi-functional composite materials in the future.
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