期刊
FEBS OPEN BIO
卷 7, 期 3, 页码 318-323出版社
WILEY
DOI: 10.1002/2211-5463.12146
关键词
feedback system control; flavonoids combination; hematological parameters
资金
- Hong Kong Research Grants Council Theme-Based Research Scheme [T13-607/12R]
- GRF [663012, 662713, M-HKUST604/13, TUYF15SC01]
- Hong Kong Jockey Club Charities Trust [HKJCCT12SC01]
By using a feedback system control scheme, the best combination of formononetin, ononin, calycosin, and calycosin-7-O-beta-D-glucoside derived from Astragali Radix was shown to activate a hypoxia response element, a regulator for erythropoietin (EPO) transcription, in kidney fibroblast. In cyclophosphamide-induced anemic rats, the treatment of combined flavonoids, or EPO, improved the levels of red blood cells, white blood cells, hemoglobin, and hematocrit. In addition, the altered levels of antioxidant capacity, super oxidase dismutase, and malondialdehyde, triggered in anemic rats, were restored to control levels by the treatment of flavonoids. Here, we proposed a possible therapy by using the common flavonoids in treating anemia.
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