期刊
CLINICAL INTERVENTIONS IN AGING
卷 12, 期 -, 页码 1637-1643出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CIA.S147588
关键词
Parkinson's disease; hyposmia; cognitive dysfunction
资金
- National Key Plan for R&D Program of China [2017YFC0909100]
- Youth fund of Jiangsu Province's Natural Science Foundation [BK20170355]
- Social development projects in Jiangsu Province [BE2017653]
- Jiangsu Province's Young Medical Talents Program [QNRC2016872]
- Suzhou Clinical Research Center of Neurological Disease [Szzx201503]
- Suzhou Science and Technology Development Program [SYS201620, SYS201624]
- National Natural Science Pre-Research Foundation of China [SDFEYGJ1605]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Objective: Hyposmia is one of the earliest non-motor features of Parkinson's disease (PD) and can precede the onset of motor symptoms by years. Most of the current olfactory detection tests are targeted at Western populations. The exact relationship between hyposmia and cognitive impairment is unknown. The purpose of the study was to find bromines that can effectively identify olfactory dysfunction and investigate the relationship between hyposmia and cognitive function in early, non-demented, drug-naive patients with PD in the People's Republic of China. Methods: Sixty-three early, non-demented, drug-naive patients with PD and 55 healthy controls were enrolled in the study. The T&T olfactometer and a Chinese version of Montreal Cognitive Assessment (MoCA) were applied to assess subjects' olfactory and cognitive functions. Patients with PD also completed the Modified Unified Parkinson's disease-rating scale (UPDRS) and Hoehn and Yahr (H&Y) scale. Results: Patients with PD had lower scores of visuospatial and executive function (p=0.000), attention (p=0.03), and delayed recall (p=0.001) than controls. beta-phenylethyl alcohol (floral smell, smell of rose petals) and isovaleric acid (smell of sweat, stuffy socks) were more sensitive for identifying hyposmia in patients with PD than three other odors. Multivariate logistic regression analysis showed that impaired visuospatial and executive function was associated with hyposmia (p=0.013), but was independent of other PD-associated variables. Conclusion: Hyposmia was common in early, non-demented, drug-naive PD patients. beta-Phenylethyl alcohol and isovaleric acid were more superior for identifying hyposmia in early non-demented Chinese patients with PD. Hyposmia was associated with impaired visuospatial and executive function in patients with PD. Further prospective studies that apply a series of neuropsychological tests and functional magnetic resonance imaging methods in large samples in multicenter studies are needed to confirm our findings and to investigate the relationship between hyposmia and cognitive function with disease progression in patients with PD.
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