期刊
CLINICAL INTERVENTIONS IN AGING
卷 12, 期 -, 页码 1339-1345出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CIA.S141265
关键词
arterial stiffness; blood pressure variability; arterial aging; telomeres
资金
- Romanian Working Group on Atherosclerosis and Atherothrombosis part of Romanian Society of Cardiology
The true onset of atherosclerosis remains one of the biggest challenges for cardiologists. Is atheroma plaque development considered the earliest step of vascular aging? If so, when it starts? Before or after birth? If it starts before birth or early during childhood, it seems that Thomas Sydenham was right: A man is as old as his arteries. Except disorganization of elastic fibers, less is known about the morphology of vascular aging and also about the molecular events influencing the age of arteries, arterial stiffness, and their role in the appearance of future complications. Cellular and molecular events responsible for the switch from physiologic to pathologic aging of human arteries are less known. Epigenetic, genetic, and environmental influences at the onset of early vascular aging (EVA) should specifically influence the process. This paper briefly reviews the controversial data regarding vascular aging with an emphasis on the less known facts about the morphology of EVA.
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