期刊
CLINICAL INTERVENTIONS IN AGING
卷 12, 期 -, 页码 1419-1428出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CIA.S145247
关键词
calorie restriction; intermittent fasting; aging; memory; macronutrients
资金
- Aging and Alzheimer's Research Institute
- National Health and Research Council of Australia (NHMRC) [571328, 1084267]
- Intramural Program of the National Institute on Aging, NIH
- American Australian Association (AAA) Education Fund
- NHMRC Peter Doherty Early Career Fellowship [1110098]
- National Health and Medical Research Council of Australia [1110098, 1084267] Funding Source: NHMRC
Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients. Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration.
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