A Reusable Palladium/Cationic 2,2'-Bipyridyl System-Catalyzed Double Mizoroki-Heck Reaction in Water

A reusable PdCl2(NH3)(2)/cationic 2,2'-bipyridyl system was used to catalyze the double Mizoroki-Heck reaction of aryl iodides with electron-deficient alkenes in water in the absence of inert gas, giving beta,beta-diarylated carbonyl derivatives in good to excellent yields. The formation of unsymmetrical beta,beta-diarylated alkenes were also studied by coupling aryl iodides with the corresponding aryl-substituted alpha,beta-unsaturated carbonyl compounds. This water-soluble catalyst can be swiftly separated from the organic layer using simple extraction for the further reuse, and, thus, makes it an operationally-simple and environmentally-benign procedure.