期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 25, 期 10, 页码 1532-1543出版社
ELSEVIER
DOI: 10.1016/j.euroneuro.2015.06.007
关键词
Depression; Inflammation; Biological markers; Depressive disorder; Treatment resistant
资金
- National Institute for Health Research (NIHR)
- NIHR Biomedical Resource Centre for Mental Health
The depressive state has been characterised as one of elevated inflammation, which holds promise for better understanding treatment-resistance in affective disorders as well as for future developments in treatment stratification. Aiming to investigate alterations in the inflammatory profiles of individuals with depression as putative biomarkers for clinical response, we conducted meta-analyses examining data from 35 studies that investigated inflammation before and after treatment in depressed patients together with a measure of clinical response. There were sufficient data to analyse IL-6, TNF alpha and CRP. Levels of IL-6 decreased with antidepressant treatment regardless of outcome, whereas persistently elevated INFO was associated with prospectively determined treatment resistance. Treatment non-responders tended to have higher baseline inflammation, using a composite measure of inflammatory markers. Our findings suggest that elevated levels of inflammation are contributory to treatment resistance. Combining inflammatory biomarkers might prove a useful tool to improve diagnosis and detection of treatment refractoriness, and targeting persistent inflammation in treatment-resistant depression may offer a potential target for the development of novel intervention strategies. (C) 2015 Elsevier B.V. and ECNR All rights reserved.
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