期刊
CANCER MEDICINE
卷 6, 期 8, 页码 1998-2007出版社
WILEY
DOI: 10.1002/cam4.1136
关键词
Head and neck neoplasms; hormone replacement therapy; mouth neoplasms; reproductive history; women
类别
资金
- US National Institutes of Health
- National Cancer Institute [R03CA113157]
- National Institute of Dental and Craniofacial Health [R03DE016611]
- Italian Association for Research on Cancer (AIRC)
- Aviano: AIRC, Italian League Against Cancer and Italian Ministry of Research
- AIRC, Italian League against Cancer and Italian Ministry of Research
- Swiss: Swiss League against Cancer
- Swiss Research against Cancer/Oncosuisse [KFS-700, OCS-1633]
- Iowa study: NIH [NIDCR] [R01DE11979, R01DE13110]
- Iowa study: NIH [NIH FIRCA] [TW01500]
- Veterans Affairs Merit Review Funds
- Rome: AIRC (Italian Agency for Research on Cancer) [14220]
- US multicentre study: Intramural Program of the NCI/NIH
- Japan: Scientific Research grant from Ministry of Education, Science, Sports, Culture and Technology of Japan [17015052]
- Third-Term Comprehensive 10-Year Strategy for Cancer Control: Ministry of Health, Labour and Welfare of Japan [H20-002]
- Grants-in-Aid for Scientific Research [17015052] Funding Source: KAKEN
Due to lower female incidence, estimates of exogenous and endogenous hormonal factors in head and neck cancers (HNCs, comprising cancers of the oral cavity, oropharynx, hypopharynx, and larynx) among women have been inconsistent and unable to account for key HNC risk factors. We pooled data from 11 studies from Europe, North America, and Japan. Analysis included 1572 HNC female cases and 4343 controls. Pooled odds ratios (ORs) estimates and their 95% confidence intervals (CIs) were calculated using multivariate logistic regression models adjusting for tobacco smoking and alcohol drinking. Lower risk was observed in women who used hormone replacement therapy (HRT) (OR = 0.58; 95% CI: 0.34-0.77). Pregnancy (OR = 0.61; 95% CI: 0.42-0.90) and giving birth (OR = 0.59; 95% CI: 0.38-0.90) at <35years of age were inversely associated with HNCs. An inverse association with HNC was observed with age at start of HRT use (OR = 0.59; 95% CI: 0.39-0.90) for each additional 10years and with duration of use (OR = 0.87; 95% CI: 0.76-0.99 for every 3years). Exogenous female hormone use is associated with a nearly twofold risk reduction in female HNCs. The lower female HNC incidence may, in part, be explained by endogenous and exogenous estrogen exposures.
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