期刊
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS
卷 6, 期 4, 页码 191-198出版社
ICE PUBLISHING
DOI: 10.1680/jbibn.16.00043
关键词
nature inspired; scaffold; soft tissue
资金
- Iran National Foundation of Elites
In the field of tissue engineering, special interest is paid to employing non-toxic, biocompatible materials and methods. Poly(vinyl alcohol) (PVA) has excellent properties for tissue engineering but is unstable in an aqueous environment. Generally, genipin is used as a low-toxicity natural cross-linker for proteins, but in this study, to increase PVA stability, a novel cross-linking modification method through the use of naturally occurring components (genipin and glycine) was performed. In tissue engineering, the fabrication of scaffolds is influenced mainly by the chemical, biological, mechanical and kinetic properties of the ingredients. In addition, the scaffold is affected by altering the polymer composition and processing parameters. Herein, the novel modified PVA was characterized by Fourier transform infrared spectroscopy, differential thermal analysis, swelling experiments and degradation tests. The modified PVA provided an effective cell support for 21 d of immersion in a phosphate-buffered saline environment, and the in vitro cell culture of PC12 nerve cells on the modified PVA scaffold showed neural adhesion and growth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据