期刊
ALLERGOLOGY INTERNATIONAL
卷 66, 期 4, 页码 539-544出版社
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.1016/j.alit.2017.08.004
关键词
Atopic dermatitis; Microbiota; Quorum sensing; Staphylococcus aureus; delta-toxin
资金
- JSPS KAKENHI [16H06252]
- NIH [R01AR069303]
- Institute for Global Prominent Research, Chiba University
- Grants-in-Aid for Scientific Research [16H06252] Funding Source: KAKEN
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15-20% of children and 2-5% of adults in industrialized countries. The pathogen Staphylococcus aureus selectively colonizes the lesional skin of AD patients while this bacterium is absent in the skin of the majority of healthy individuals. However, the role of S. aureus in the pathogenesis of AD remains poorly understood. In addition to S. aureus, recent studies show a contribution of the skin microbiota to the regulation of immune responses in the skin as well as to the development of inflammatory skin disease. This review summarizes current knowledge about the role of the microbiota in skin immune responses and the role of S. aureus virulent factors in the pathogenesis of AD. Copyright (C) 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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