期刊
AMERICAN JOURNAL OF CASE REPORTS
卷 17, 期 -, 页码 625-631出版社
INT SCIENTIFIC LITERATURE, INC
DOI: 10.12659/AJCR.899149
关键词
Drug Hypersensitivity Syndrome; Lung Diseases; Interstitial; Teicoplanin; Vancomycin
资金
- Tokushukai Hospital, Japan [150178PK]
- Grants-in-Aid for Scientific Research [25460645] Funding Source: KAKEN
Objective: Adverse events of drug therapy Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening syndrome comprising severe skin eruption, fever, eosinophilia, lymphadenopathy, and involvement of internal organs. Here, we describe a case of DRESS syndrome caused by cross-reactivity between vancomycin and subsequent teicoplanin administration. Case Report: A 79-year-old male was admitted to our hospital for the treatment of injuries incurred in a traffic accident. Eosinophilia and lung dysfunction appeared after vancomycin administration. These symptoms were improved temporarily by withdrawal of vancomycin and administration of corticosteroid, but exacerbated by subsequent teicoplanin administration. These symptoms disappeared after discontinuation of teicoplanin. Based on comprehensive assessment of the overall clinical course, we judged that DRESS syndrome was induced by cross-reactivity between vancomycin and subsequent teicoplanin administration. Using the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) scoring system, we categorized DRESS syndrome related to vancomycin and teicoplanin as probable. We describe, for the first time, DRESS syndrome (defined using the RegiSCAR scoring system) caused by cross-reactivity between vancomycin and subsequent teicoplanin administration. Conclusions: Clinicians should be aware that DRESS syndrome can be induced by cross-reactivity between vancomycin and teicoplanin.
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