期刊
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
卷 10, 期 6, 页码 ZC28-ZC31出版社
PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
DOI: 10.7860/JCDR/2016/19189.7966
关键词
Antigens; Antigen presentation; Dendritic cells; Mouth mucosa
Introduction: Langerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-Iymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen. Aim: The aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium. Materials and Methods: A retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed Dentistry Section using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test. Results: LC population in OLP was significantly higher when compared to the normal epithelium (p<0.001). Conclusion: The increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-Iymphocytes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据