期刊
SYMMETRY-BASEL
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/sym9100206
关键词
enantioresolution; preparative scale; membranes
资金
- FCT/MCTES-Foundation for Science and Technology from the Minister of Science, Technology and Higher Education (PIDDAC)
- European Regional Development Fund (ERDF) through COMPETE-Programa Operacional Factores de Competitividade (POFC) programme [UID/Multi/04423/2013, PTDC/MAR-BIO/4694/2014, POCI-01-0145-FEDER-016790]
- Project 3599-Promover Producao Cientifica e Desenvolvimento Tecnologico e a Constituicao de Redes Tematicas (3599-PPCDT)
- project INNOVMAR-Innovation and Sustainability in the Management and Exploitation of Marine Resources within Research Line NOVELMAR [NORTE-01-0145-FEDER-000035]
- North Portugal Regional Operational Programme (NORTE), under PORTUGAL, through the European Regional Development Fund (ERDF)
- Chiral_Drugs_CESPU
Given the importance of chirality in the biological response, regulators, industries and researchers require chiral compounds in their enantiomeric pure form. Therefore, the approach to separate enantiomers in preparative scale needs to be fast, easy to operate, low cost and allow obtaining the enantiomers at high level of optical purity. A variety of methodologies to separate enantiomers in preparative scale is described, but most of them are expensive or with restricted applicability. However, the use of membranes have been pointed out as a promising methodology for scale-up enantiomeric separation due to the low energy consumption, continuous operability, variety of materials and supports, simplicity, eco-friendly and the possibility to be integrated into other separation processes. Different types of membranes (solid and liquid) have been developed and may provide applicability in multi-milligram and industrial scales. In this brief overview, the different types and chemical nature of membranes are described, showing their advantages and drawbacks. Recent applications of enantiomeric separations of pharmaceuticals, amines and amino acids were reported.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据