期刊
STEM CELLS INTERNATIONAL
卷 2017, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2017/2857478
关键词
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资金
- National Natural Science Foundation of China [81301350, 81371718]
- Basic and Advanced Research Projects in Chongqing [cstc2013jcyjA10021]
- China Postdoctoral Science Foundation [2016M590866]
- Fundamental Research Funds for the Central Universities [106112015CDJRC231206]
- Special Funding for Postdoctoral Research Projects in Chongqing [Xm2015093]
- China Scholarship Council [2011605042]
Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-related protein 4 (sFRP4) is preferentially expressed in the skin epidermal cells rather than in melanocytes. By overexpression of sFRP4 in skin cells in vivo and in vitro, we found that sFRP4 attenuates activation of Wnt signaling, resulting in decrease of melanocytes differentiation in the regenerating hair follicle. Our findings unveiled a new regulator that involves modulating melanocytes differentiation through a paracrine mechanism in hair follicle, supplying a hope for potential therapeutic application to treat skin pigmentation disorders.
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