期刊
STEM CELLS INTERNATIONAL
卷 2017, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2017/8596135
关键词
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资金
- National Basic Research Program of China [2015CB943000]
- National Natural Science Foundation of China [31471225]
- Major Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology [2016FXCX006]
- Open Project of the CAS Key Laboratory of Innate Immunity and Chronic Disease [KLIICD-201603]
DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism. In this study, we found that DDX3 interacted with ALKBH5, an m(6)A RNA demethylase. The ATP domain of DDX3 and DSBH domain of ALKBH5 were indispensable to their interaction with each other. Furthermore, DDX3 could modulate the demethylation of mRNAs. We also showed that DDX3 regulated the methylation status of microRNAs and there was an interaction between DDX3 and AGO2. The dynamics of m(6)A RNA modification is still a field demanding further investigation, and here, we add a link by showing that RNA demethylation can be regulated by proteins such as DDX3.
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