The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells

Small cell lung cancer (NSCLC) accounts for 85% of total deaths globally, and recent studies indicate the increasing risks of NSCLC in China and South Asian countries. Hence, development of new therapeutics against NSCLC has been a major concern. alpha-Mangostin, a naturally occurring xanthone, found abundantly in pericarps of mangosteen fruit is well known for its medicinal importance. The anticancer properties of alpha-mangostin against several types of cancer are also well documented. But the mechanism of action of alpha-mangostin against lung cancer is not well understood and requires further investigation. Therefore in the present study, we explored the therapeutic potential of alpha-mangostin against A549 cells. Treatment of A549 cells with alpha-mangostin resulted in a dose-dependent loss of cell viability, while the non-malignant cells such as hPBMC and WI-38 remained unaffected. Further we observed that the ROS plays an important role in alpha-mangostin -induced apoptosis in A549 cells, and administration of N-acetyl cysteine significantly abrogates alpha-mangostin -mediated cytotoxicity in lung cancer cells. Overall, alpha-mangostin induces ROS-mediated cytotoxicity in NSCLC cells. (C) 2017 The Authors. Production and hosting by Elsevier B.V.