期刊
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
卷 24, 期 4, 页码 950-955出版社
ELSEVIER
DOI: 10.1016/j.sjbs.2016.01.033
关键词
Albizia adianthifolia; Antibacterial activity; Gram-negative bacteria; Laportea ovalifolia; Medicinal plants; Multidrug resistance
类别
In the last 10 years, resistance in Gram-negative bacteria has been increasing. The present study was designed to evaluate the in vitro antibacterial activities of the methanol extracts of six Cameroonian medicinal plants Albizia adianthifolia, Alchornea laxiflora, Boerhavia diffusa, Combretum hispidum, Laportea ovalifolia and Scoparia dulcis against a panel of 15 multidrug resistant Gram-negative bacterial strains. The broth microdilution was used to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the extracts. The preliminary phytochemical screening of the extracts was conducted according to the reference qualitative phytochemical methods. Results showed that all extracts contained compounds belonging to the classes of polyphenols and triterpenes, other classes of chemicals being selectively distributed. The best antibacterial activities were recorded with bark and root extracts of A. adianthifolia as well as with L. ovalifolia extract, with MIC values ranging from 64 to 1024 mu g/mL on 93.3% of the fifteen tested bacteria. The lowest MIC value of 64 mu g/mL was recorded with A. laxiflora bark extract against Enterobacter aerogenes EA289. Finally, the results of this study provide evidence of the antibacterial activity of the tested plants and suggest their possible use in the control of multidrug resistant phenotypes. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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