期刊
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
卷 24, 期 4, 页码 760-766出版社
ELSEVIER
DOI: 10.1016/j.sjbs.2017.01.001
关键词
Cisplatin; Histopathology; Lipid peroxidation; Nephrotoxicity; Phytochemical screening
类别
资金
- Deanship of Scientific Research at King Saud University, Saudi Arabia [RG-1437-002]
Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protective effect of hydroalcoholic extract of P. zeylanica (HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice. Treatment with higher dose (400 mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect. The antioxidant effect of the drug is evident from its significant effect on Catalase, Glutathione peroxidase and lipid peroxidation activities. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
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