期刊
EUROPEAN NEUROPSYCHOPHARMACOLOGY
卷 25, 期 2, 页码 257-264出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.euroneuro.2014.05.010
关键词
Bipolar II disorder; Cognitive impairment; Cognitive functioning; Cognitive remediation; Subsyndromic depressive symptoms
资金
- Spanish Ministry of Economy and Competitiveness [PI080180, PI08/90825, PI08/90327, PI08/90675, PI08/90224, PI08/90654, PI08/90189, PI08/90916, PI08/90416, PI08/90094]
- Instituto de Salud Carlos III, Subdireccion General de Evaluacion y Fomento de la Investigacian
- Fondo Europeo de Desarrollo Regional. Union Europea, Una manera de hacer Europa
- CIBERSAM
- Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya
- Esther Koplowitz Centre (CEK)
- Brain and Behavior Research Foundation
Recently, Functional Remediation (FR) has proven to be effective in improving the functional outcome of euthymic bipolar patients. The aim of this study was to test the efficacy of the FR program in a subsample of euthymic bipolar II patients (BPII). A post-hoc analyses were undertaken using data of 53 BPII outpatients who had participated in a multicenter, rater-blind, randomized, controlled trial exploring the efficacy of FR (n=17) as compared with a Psychoeducation group (PSY) (n=19) and a treatment as usual control group (TAU n=17). The primary outcome variable was the functional improvement defined as the mean change in the Functioning Assessment Short Test (FAST) from baseline to endpoint after the intervention. Regarding the treatment effect, data reveal a significant functional improvement from baseline to endpoint, suggestive for an interaction between program pertinence and time (pre-post). Nevertheless, Tukey's post-hoc test only revealed a trend in favor of a better outcome for FR when compared to the other two groups. We also found an interaction between program pertinence and time when analysing the subdepressive symptoms, with BPII! patients in FR showing a significant reduction when compared to the PSY group. Our results suggest that the FR appears to be effective in improving the overall functional outcome in BPII, as well as in reducing subdepressive symptoms. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
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