期刊
PATHOGENS AND DISEASE
卷 75, 期 4, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftx044
关键词
Mycoplasma pneumonia; lipid-associated membrane proteins (LAMPs); nuclear factor E2-related factor 2 (Nrf2); inflammatory reactant; heme oxygenase-1 (HO-1)
资金
- Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]
- construct program of the key discipline in Hunan province for Preclinical Medicine and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2012-1, 2014-405]
- Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]
A series of inflammatory responses caused by Mycoplasma pneumoniae largely depend on the lipid-associated membrane proteins (LAMPs). Nuclear factor E2-related factor 2 (Nrf2), a transcription factor, is considered to be a critical modulator of inflammatory responses and cellular redox homeostasis. Monocytes play an important role in the invasion and immunity to resist pathogens. Here, we investigated the role of Nrf2 in the anti-inflammatory response stimulated by LAMPs using the human monocyte cell line THP-1. LAMPs were shown to affect the localization of Nrf2, and the levels of reactive oxygen species and inflammatory reactants, including nitric oxide (NO), prostaglandin E2 (PGE(2)) and cytokines (IL-6, IL-8), were highly elevated in LAMP-stimulated Nrf2-silenced THP-1 cells. Moreover, LAMPs induced the levels of mRNA and the expression of heme oxygenase-1 (HO-1). In summary, our results demonstrated that LAMPs cause nuclear translocation of Nrf2, which further suppresses the expression of inflammatory reactants in THP-1 cells.
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