期刊
PATHOGENS AND DISEASE
卷 75, 期 6, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftx061
关键词
Candida albicans; Candida glabrata; single nucleotide polymorphisms (SNP); clinical isolates; yeast infection
资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [F31AI116023, UH2AI083264]
Candida albicans is the predominant cause of vulvovaginal candidiasis (VVC). Little is known regarding the genetic diversity of Candida spp. in the vagina or the microvariations in strains over time that may contribute to the development of VVC. This study reports the draft genome sequences of four C. albicans and one C. glabrata strains isolated from women with VVC. An SNP-based whole-genome phylogeny indicates that these isolates are closely related; however, phylogenetic distances between them suggest that there may be genetic adaptations driven by unique host environments. These sequences will facilitate further comparative analyses and ultimately improve our understanding of genetic variation in isolates of Candida spp. that are associated with VVC.
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