3.8 Article

Formulation and Drug Loading Features of Nano-Erythrocytes

期刊

NANOSCALE RESEARCH LETTERS
卷 12, 期 -, 页码 -

出版社

SPRINGEROPEN
DOI: 10.1186/s11671-017-1980-5

关键词

STS; Erythrocyte ghosts; Drug delivery; Repairing effect

资金

  1. Guangdong Natural Science Foundation [2014A030310362]
  2. Science and Technology Program of Guangzhou [201508010036]
  3. IAR Collaborative Innovation Project of Guangzhou [201605131249066]

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Nano erythrocyte ghosts have recently been used as drug carriers of water-soluble APIs due to inherit biological characteristics of good compatibility, low toxicity, and small side-effect. In this study, we developed a novel drug delivery system based on nano erythrocyte ghosts (STS-Nano-RBCs) to transport Sodium Tanshinone IIA sulfonate (STS) for intravenous use in rat. STS-Nano-RBCs were prepared by hypotonic lysis and by extrusion methods, and its biological properties were investigated compared with STS injection. The results revealed that STS-Nano-RBCs have narrow particle size distribution, good drug loading efficiency, and good stability within 21 days. Compared with STS injection, STS-Nano-RBCs extended the drug release time in vitro and in vivo with better repairing effect on oxidative stress-impaired endothelial cells. These results suggest that the nano erythrocyte ghosts system could be used to deliver STS.

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