期刊
NANOSCALE RESEARCH LETTERS
卷 12, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1186/s11671-017-2317-0
关键词
Graphene; Graphene oxide; Nanoparticles; Bone marrow mesenchymal stem cells; Biocompatibility; Antibacterial ability
资金
- National Natural Science Foundation of China [81301569, 81371982]
- State Key Project of Research and Development [2016YFC1100300]
In recent years, graphene (G) and graphene oxide (GO) nanoparticles have begun to be applied in surgical implant surface modification. However, biosafety and antibacterial ability of G and GO are still unclear. In this study, the biosafety of G and GO in vitro was evaluated by co-culture with bone marrow mesenchymal stem cells (BMSCs) and biosafety in vivo was observed by implanting materials into mice muscle tissue. Biosafety results showed that 10 mu g/ml was the safety critical concentration for G and GO. When the concentration was more than 10 mu g/ml, the cytotoxicity of G and GO showed a dose-dependent manner. Antibacterial results showed that G presented the antibacterial ability with the concentration equal to and more than 100 mu g/ml; GO presented the antibacterial ability with the concentration equal to and more than 50 mu g/ml. The antibacterial effect of G and GO were in a dose-dependent manner in vitro. The GO or G concentration between 50 and 100 mu g/ml may be the better range to keep the balance of cytotoxicity and antibacterial ability. Our study reveals that G and GO have potential to be used in clinic with good biosafety and antibacterial properties in a certain concentration range.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据