期刊
MEDICAL SCIENCE MONITOR
卷 23, 期 -, 页码 1232-1241出版社
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.902454
关键词
Arthritis; Autoantibodies; T-Lymphocytes
资金
- National Natural Science Foundation of China [81360459]
- Jiangxi Provincial Natural Science Foundation of China [20151BAB215031]
Background: It is well known that lymphocytes play an important role in rheumatoid arthritis (RA). T cell immunoreceptors with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (TIGIT) have immunosuppressive co-stimulatory molecules that mediate inhibitory effects, but their roles in RA are poorly understood. Material/Methods: Were recruited 76 patients with RA and 33 healthy controls (HC). Clinical manifestations, laboratory measurements, physical examination, and medical history of RA patients were recorded. The expression of TIGIT on CD3(+) T lymphocytes, B lymphocytes, monocytes, neutrophils, CD3(+) CD4(+) T lymphocytes, and CD3(+) CD8(+) T lymphocytes was determined using flow cytometry. The expression of TIGIT on T lymphocytes in patients with RA was further analyzed to investigate its correlations with markers of autoimmune response, inflammation, and disease activity in RA. Results: Compared with HC, the expression levels of TIGIT on CD3(+) CD4(+) T lymphocytes and CD3(+) CD8(+) T lymphocytes were significantly increased in patients with RA (P < 0.01). The frequency of TIGIT-expressing CD3(+) CD4+ T lymphocytes was positively correlated with RF, increased ACPA, ESR, and CRP levels. The frequency of TIGIT-expressing CD3(+) CD8(+) T lymphocytes was positively correlated with RF and ESR levels. Furthermore, the expression level of TIGIT on CD3(+) CD4(+) T lymphocytes was positively correlated with the DAS28 score in RA. Conclusions: The expression levels of TIGIT on T lymphocytes were elevated and correlated with disease activity in RA.
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