期刊
MEDICAL SCIENCE MONITOR
卷 23, 期 -, 页码 2897-2905出版社
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.904486
关键词
Chemotherapy, Adjuvant; Colorectal Neoplasms; Vimentin
资金
- CSCO-Merck Serono Oncology Research [Y-MX2015-046]
Background: Increased expression of vimentin in tissue samples from patients with colorectal cancer (CRC) has been previously demonstrated, but its prognostic significance remains controversial, and the clinical significance for patients with stage II CRC is still unknown. The aim of this study was to evaluate the expression of vimentin in CRC and its potential prognostic significance. Material/Methods: We analyzed vimentin expression in 203 CRC tissue samples from patients with stage II cancer using immunohistochemistry, and correlated the findings with clinicopathological patient features. CRC-specific survival (CSS) and disease-free survival (DFS) were analyzed using the Kaplan-Meier method. Univariate and multivariate analysis was performed using the Cox proportional hazards method for survival. Results: Vimentin expression was significantly correlated only with tumor (T) stage (p= 0.024). Kaplan-Meier survival analysis indicated that vimentin expression could stratify the CSS and DFS of patients with stage II CRC at high risk (p= 0.029, p= 0.042, respectively), but not those of low-risk stage II patients (p= 0.208, p= 0.361, respectively). Univariate and multivariate analysis further revealed that stromal vimentin expression is an independent prognostic factor for CSS and DFS of high-risk stage II patients (p= 0.043, p= 0.022, respectively). Moreover, high-risk stage II patients with low stromal vimentin expression benefitted more from standard adjuvant chemotherapy than those with high stromal vimentin expression (CSS: p= 0.012 vs. p= 0.407; DFS: p= 0.017 vs. p= 0.420). Conclusions: Our study suggests that stromal vimentin expression is a promising indicator for survival prediction and adjuvant chemotherapy response in patients with stage II CRC with high-risk factors for recurrence.
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