期刊
LIGHT-SCIENCE & APPLICATIONS
卷 6, 期 -, 页码 -出版社
CHINESE ACAD SCIENCES, CHANGCHUN INST OPTICS FINE MECHANICS AND PHYSICS
DOI: 10.1038/lsa.2016.278
关键词
all optical; medical imaging; optical resolution; photoacoustic; remote sensing
类别
资金
- Killam Trust (Izaak Walton Killam Memorial Scholarship)
- Alberta Innovates Technology Futures
- Alberta Enterprise and Advanced Education
- University of Alberta
- Andrew Stewart Awards
- SPIE (SPIE Scholarship in Optics and Photonics)
- NSERC [355544-2008, 375340-2009, STPGP 396444]
- Terry-Fox Foundation
- Canadian Cancer Society [TFF 019237, TFF 019240, CCS 2011-700718]
- Alberta Innovates Health Solutions (AIHS) [201201154]
- Alberta Cancer Research Institute [ACB 23728]
- Leaders Opportunity Fund of the Canada Foundation for Innovation [18472]
- Alberta Advanced Education and Technology, Small Equipment Grants Program [URSI09007SEG]
- Alberta Ingenuity/Alberta Innovates
- Alberta Innovates Technology Futures Postdoctoral Fellowship
Elasto-optical refractive index modulation due to photoacoustic initial pressure transients produced significant reflection of a probe beam when the absorbing interface had an appreciable refractive index difference. This effect was harnessed in a new form of non-contact optical resolution photoacoustic microscopy called photoacoustic remote sensing microscopy. A non-interferometric system architecture with a low-coherence probe beam precludes detection of surface oscillations and other phase-modulation phenomenon. The probe beam was confocal with a scanned excitation beam to ensure detection of initial pressure-induced intensity reflections at the subsurface origin where pressures are largest. Phantom studies confirmed signal dependence on optical absorption, index contrast and excitation fluence. In vivo imaging of superficial microvasculature and melanoma tumors was demonstrated with similar to 2.7 +/- 0.5 mu m lateral resolution.
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