期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2016.00027
关键词
systems medicine; cardiovascular disease; omics; networks; functional characterization
资金
- German Center of Cardiovascular Research (DZHK e.V.) [FKZ 81Z1710101]
- BMBF (German Federal Ministry of Education and Research) [01ZX1408A]
- Else Kroner-Fresenius-Stiftung [2014_A92]
Cardiovascular disease (CVD) is a major contributor to morbidity and mortality worldwide. However, the pathogenesis of CVD is complex and remains elusive. Within the last years, systems medicine has emerged as a novel tool to study the complex genetic, molecular, and physiological interactions leading to diseases. In this review, we provide an overview about the current approaches for systems medicine in CVD. They include bioinformatical and experimental tools such as cell and animal models, omics technologies, network, and pathway analyses. Additionally, we discuss challenges and current literature examples where systems medicine has been successfully applied for the study of CVD.
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