期刊
CLINICAL PSYCHOLOGICAL SCIENCE
卷 4, 期 6, 页码 1125-1134出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2167702616645777
关键词
depression; dietary inflammatory index; epidemiology; cohort study
资金
- British Medical Research Council [MR/K013351]
- British Heart Foundation [PG/11/63/29011, RG/13/2/30098]
- British Health and Safety Executive
- British Department of Health
- National Heart, Lung, and Blood Institute [R01HL036310]
- National Institute on Aging, National Institute of Health [R01AG013196, R01AG034454]
- Economic and Social Research Council [ES/J023299]
- Medical Research Council, United Kingdom [K013351]
- NordForsk, the Nordic Research Programme on Health and Welfare
- Economic and Social Research Council
- Languedoc Roussillon district in South of France (Aide a la recherche en partenariat avec les Entreprises)
- U.S. National Institute of Diabetes and Digestive and Kidney Diseases [R44DK103377]
- British Heart Foundation [RG/13/2/30098] Funding Source: researchfish
There is a growing interest in understanding the role of inflammation in the diet-depression relationship. The present study examined whether the Dietary Inflammatory Index (DII; a measure of the inflammatory potential of individuals' diets) is associated with recurrent depressive symptoms (DepS) (Center for Epidemiologic Studies Depression Scale score > 16 or taking antidepressants both at baseline and follow-up) assessed over 5 years in middle-aged men (n = 3,178) and women (n = 1,068) from the Whitehall II Study. For each increment of 1 SD of DII score, odds of recurrent DepS increased by 66% (95% confidence interval [CI] = [1.30, 2.12]) in women, whereas no significant association between DII and recurrent DepS was observed in men (odds ratio [OR] = 1.12; 95% CI = [0.92, 1.36]). This association was little attenuated after adjustment for confounders and after taking into account levels of interleukin-6 and C-reactive protein. In conclusion, there is an association between proinflammatory diet and recurrent DepS in women that seems to not be driven by circulating inflammatory markers.
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