期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 28, 页码 15474-15480出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b03755
关键词
electrochemical sensor; molecularly imprinted polymer; nanoporous nickel; metronidazole; trace level measurement
资金
- National Natural Science Foundation of China [81260487, 81460543]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars from Ministry of Human Resources and Social Security of China [RSLX201301]
- Major Program for Science and Technology Development of Shihezi University [gxjs2014-zdgg04]
- Pairing Program of Shihezi University with Eminent Scholar in Elite University [SDJDZ201502]
A novel electrochemical sensor has been developed by using a composite element of three-dimensional (SD) nanoporous nickel (NPNi) and molecularly imprinted polymer (MIP). NPNi is introduced in order to enhance the electron-transport ability and surface area of the sensor, while the electro-synthesized MIP layer affords simultaneous identification and quantification of the target molecule by employing Fe(CN)(6)(3-/4-) as the probe to indicate the current intensity. The morphology of the hybrid film was observed by scanning electron microscopy, and the properties of the sensor were examined by cyclic voltammetry and electrochemical impedance spectroscopy. By using metronidazole (MNZ) as a model analyte, the sensor based on the MIP/NPNi hybrid exhibits great features such as a remarkably low detection limit of 2 x 10(-14) M (S/N = 3), superb selectivity in discriminating MNZ from its structural analogues, and good antiinterference ability toward several coexisting substances. Moreover, the proposed method also demonstrates excellent repeatability and stability, with relative standard deviations of less than 1.12% and 1.4%, respectively. Analysis of MNZ in pharmaceutical dosage form and fish tissue is successfully carried out without assistance of complicated pretreatment. The MIP/NPNi composite presented here with admirable merits makes it a promising candidate for developing electrochemical sensor devices and plays a role in widespread fields.
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