期刊
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
卷 83, 期 4, 页码 736-741出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TA.0000000000001638
关键词
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资金
- Chief Scientist Office of the Scottish Government Health and Social Care Directorates
- National Institute for Health Research Health Technology Assessment program [14/199/09]
- MRC Network of Hubs for Trials Methodology Research [MR/L004933/1-R/N/P/B1]
- Chief Scientist Office [HSRU1, HERU1] Funding Source: researchfish
- Medical Research Council [MR/L004933/2, MR/K025635/1, MR/L004933/1] Funding Source: researchfish
- National Institute for Health Research [14/199/09] Funding Source: researchfish
- MRC [MR/L004933/2, MR/K025635/1, MR/L004933/1] Funding Source: UKRI
Conducting clinical trials in trauma care is challenging. As new treatments become available, we are faced with the dilemma of how to confirm their effectiveness and strengthen the evidence base. Randomized controlled trials are the criterion standard, but target groups in trauma care are often small and specialized, making the classic approach to trial design difficult. Bayesian designs represent an innovative means of increasing trial efficiency and conducting trials with more realistic sample sizes. This article examines the design of such trials, using the UK-REBOA Trial as an example. Copyright (C) 2017 The Author(s).
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