期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12951-017-0308-z
关键词
Nanoparticles; Metals; ROS; Mechanism of defense; Bacteria; Transcriptomics; Proteomics; Gene regulation; Antibacterial resistance
资金
- Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)
- Canadian Institute of Health Research [01369-000]
As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据