期刊
BONE
卷 94, 期 -, 页码 42-49出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2016.10.002
关键词
Osteoclasts; Biomechanics; Matrix mineralization; Nano indentation; Raman spectroscopy
资金
- [ANR-10-EQPX-06-01 IVTV]
- [ANR-11-BS09-036-01 OMBIOS]
Human cortical bone permanently remodels itself resulting in a haversian microstructure with heterogeneous mechanical and mineral properties. Remodeling is carried out by a subtle equilibrium between bone formation by osteoblasts and bone degradation by osteoclasts. The mechanisms regulating osteoclast activity were studied using easy access supports whose homogeneous microstructures differ from human bone microstructure. In the current study, we show that human osteoclasts resorb human cortical bone non-randomly with respect to this specific human bone microstructural heterogeneity. The characterization of this new resorption profile demonstrates that osteoclasts preferentially resorb particular osteons that have weak mechanical properties and mineral contents and that contain small hydroxyapatite crystals with a high carbonate content. Therefore, the influence of human bone microstructure heterogeneity on osteoclast activity could be a key parameter for osteoclast behaviour, for both in vitro and clinical studies. (C) 2016 Elsevier Inc. All rights reserved.
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