期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 5, 期 3, 页码 537-552出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb02329k
关键词
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资金
- National Natural Science Foundation of China [50802032]
- Key Project of Natural Science Foundation of Hubei Province [2011CDA092]
- Key Scientific Project of Wuhan City [2013011801010598]
- Scientific Project of AQSIQ [2013IK093]
- self-determined research funds of CCNU from the colleges' basic research and operation of MOE [CCNU15A02035]
- plan of preeminent doctoral dissertation [2015YBYB013]
Osteogenesis and angiogenesis have been considered to be the most direct and necessary requirements for Ti-based implants used in bone regeneration. In this study, an alveolate double-layered SrTiO3 nanogridding (NG-Sr) was obtained using two steps of anodization followed by a hydrothermal process. Different Sr gradient contents (NG-Sr0.02, NG-Sr0.04, NG-Sr0.08, NG-Sr0.12 and NG-Sr0.16) were generated by altering the precursor solution concentrations. The in vitro studies indicated that NG-Sr samples with nanoscale topography and long-lasting Sr release could enhance the biofunction of both osteoblast-like cells (MC3T3-E1 cells) and human umbilical vein endothelial cells (HUVECs) to varying degrees. The NG-Sr0.08 was the optimal substrate for MC3T3-E1 cell growth, while the NG-Sr0.04 was the best choice for HUVEC growth. In vivo X-ray analysis and histological observations demonstrated that the NG-Sr0.08 samples had notable osteogenesis and angiogenesis, as significant new bone formation and fresh blood vessels were observed. Hence, the nanoscale topography with sufficient Sr supplementation offers a new independent regulator of two types of cell growth, which should be considered in biomaterial design for regenerative medicine.
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