期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 5, 期 4, 页码 817-825出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6tb02040b
关键词
-
资金
- Slovak Research and Development Agency [APVV-15-0520]
- [VVGS-PF-2016-72609]
A stimuli-responsive drug delivery system consisting of mesoporous silica with its surface modified by p-coumaric acid derivatives (CA) as photo-switchable ligands was studied for the delivery of the non-steroidal anti-inflammatory drug (NSAID) naproxen. For this purpose, MCM-41 mesoporous silica material was prepared and post-synthetically modified by the grafting of a triethoxysilyl derivative of p-coumaric acid, which undergoes a reversible photo-dimerization under UV irradiation and creates the valves'' on the surface of silica allowing targeted opening/closing of the pores. Naproxen was encapsulated into grafted MCM-41 and drug release studies were performed in two different media, in a simulated gastric fluid (pH = 2) and in a simulated body fluid (pH = 7.4). Differences in drug release were observed after irradiation of the material using UV light at lambda = 365 nm (closed pore configuration) and UV light at lambda = 254 nm (opened pore configuration).
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