期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 5, 期 22, 页码 4121-4127出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb00746a
关键词
-
资金
- National Natural Science Foundation of China [51273189]
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2016ZX05016, 2016ZX05046]
Injectable self-healing hydrogels have found broad applications in drug delivery, tissue engineering and controlled 3D cell culture. Recently, cyclic disulfides were found to be useful in cross-linking and stabilizing liposomes by disulfide exchange polymerization, benefiting from the enhanced reactivity of the disulfide bonds. Herein, we report an injectable self-healing hydrogel constructed from cross-linked F127 with thermo and pH dual responsivity. The rapid sol-gel transition ability at body temperature allows it to be used as an injectable hydrogel. And the increased reactivity of the disulfides of cyclic dithiolane due to the ring tension makes the hydrogel self-heal under not only alkaline conditions but also neutral or even mildly acidic conditions.
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