期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 5, 期 35, 页码 7403-7414出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01648d
关键词
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资金
- Qingdao Innovation Leading Talent Program
- NSF of China [51173087]
- Taishan Scholars Program
To improve cancer therapeutic efficacy and avoid side effects on normal tissues, a targeted chemo-photothermal nanoplatform was designed based on transferrin-decorated and MoS2-capped hollow mesoporous silica nanospheres. MoS2 nanosheets acted as a gatekeeper to prevent the leakage of DOX from the drug delivery system as well as the photothermal agent (PTA) to improve the therapeutic effect and facilitate the NIR-triggered endosomal escape. In this work, MoS2 nanosheets were anchored on the surface of hollow mesoporous silica nanospheres (HMSNs) via the formation of disulfide bonds (-S-S), which could be easily cleaved in the presence of the intracellular GSH, leading to stimuli-responsive drug release from the hollow mesoporous silica nanocarriers. Moreover, to further improve the tumor specificity and cellular uptake of the anti-cancer drug, the nanocarrier surface was also modified with the targeting ligand transferrin via -S-S linkage. The results demonstrated that the transferrin-decorated, MoS2-capped HMSNs can be utilized as a targeting chemo-photothermal synergetic system with high therapeutic efficacy.
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