期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 5, 期 27, 页码 5380-5389出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7tb01017f
关键词
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资金
- National Natural Science Foundation of China [21504046]
- Natural Science Foundation of Jiangsu Province [BK20150970]
- University Science Research Project of Jiangsu Province [15KJB430020]
- Jiangsu Province Science and Technology Support Program-Social Development Project [BE2013716]
- Nanjing Normal University [184080H20192]
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
Developing a facile but efficient anti-fouling surface coating is highly required for metallic implants. Here, we report two kinds of zwitterionic copolymers (both random and block) bearing phosphonic/phosphonate motifs/segments as novel metal anchorable antifouling coatings. Through conventional free radical polymerization and reversible addition-fragmentation chain transfer (RAFT) polymerization, three types of zwitterionic-phosphonic random copolymers with varying mol. ratios (9 : 1, 8 : 2, and 6 : 4) and a phosphonate-zwitterionic block copolymer were precisely prepared based on zwitterionic sulfobetaine methacrylate (SBMA) and phosphonate/phosphonic methacrylate. As evidenced by XPS and water contact angle tests, the two kinds of copolymers with distinguished presenting manners of the metal-anchorable phosphonate/phosphonic motifs were all successfully immobilized on the Ti substrates through a facile one-step post-functionalization. The immobilized copolymers equally exhibited strong inhibition of protein adsorption, platelet adhesion, and bacterial adhesion, endowing significantly improved antifouling ability to the metallic substrates. This work not only provides a novel approach to improve the antifouling ability of Ti substrates, the utilization of phosphonic/phosphonate based copolymers as efficient metal-anchorable coatings may offer a new platform for versatile surface functionalization of many metallic substrates.
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