期刊
JOURNAL OF MATERIALS CHEMISTRY A
卷 5, 期 36, 页码 19378-19389出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ta03959j
关键词
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资金
- National Natural Science Foundation of China [U1604127, 21601161, 21471134]
- Innovative Technology Team of Henan Province [CXTD2014042]
- Plan for Scientific Innovation Talent of Henan Province [154200510011]
- Innovation Scientists and Technicians Troop Construction Projects of Henan Province [152101510003]
- Program for Science & Technology Innovative Research Team in University of Henan Province [15IRTSTHN-002]
A series of nanocomposites comprised of iron oxide and mesoporous carbon (denoted as Fe3O4@mC) were derived from an Fe(II)-based metal-organic framework (525-MOF) by calcining at different temperatures. The advantages of chemical functionality, strong bioaffinity, and high stability of the Fe3O4@mC can be combined with the high specific surface area of 525-MOF leading to the formation of Fe3O4@mC nanocomposites as a scaffold for oxytetracycline (OTC) aptamer strands. The use of Fe3O4@mC nanocomposites reveals high OTC detection efficiency. The nanocomposite calcined at 900 degrees C (denoted as Fe3O4@mC(900)) is found to be the best candidate toward high-sensitivity and high-selectivity detection of OTC because of its excellent functionality, nanostructural properties, and high electrochemical performance. Accordingly, the Fe3O4@mC(900)-based electrochemical aptasensor displays high sensitivity with a low detection limit of 0.027 pg mL(-1) within a broad linear range of OTC concentration from 0.005 to 1.0 ng mL(-1). The aptasensor also exhibits high selectivity, reproducibility, stability, regenerability, and applicability in milk samples. All of these results indicate that the Fe3O4@mC nanocomposites that originated from 525-MOF can be applied in the fields of trace and fast antibiotic determination.
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