期刊
CHROMOSOME SEGREGATION AND STRUCTURE, VOL 82, 2017
卷 82, 期 -, 页码 329-338出版社
COLD SPRING HARBOR LABORATORY PRESS
DOI: 10.1101/sqb.2017.82.035006
关键词
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资金
- Olayan Fellowship
- MSK Cancer Center Support Grant/Core Grant [P30 CA008748]
- Geoffrey Beene Cancer Research Center Grant
- National Institutes of Health (NIH) [R01 CA185660]
BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.
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