期刊
BRITISH JOURNAL OF PSYCHIATRY
卷 210, 期 1, 页码 67-74出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.115.164020
关键词
-
类别
资金
- Dutch Organization for Scientific Research (NWO) [912-02-050, 907-00-012, 940-37- 018, 916.86.0381]
- Carlos III Health Institute [PI09/01331, PI10/01753, PI10/01003, CP10/00604, PI13/01958, CIBER-CB06/03/0034]
- Agency for Administration of University and Research (AGAUR, Barcelona) [2009SGR1554]
- Ministry of Education, Culture, Sports, Science, and Technology (Japan) [23591724, 24791223]
- Wellcome Trust [064846]
- Foundation for the Support of Research in the State of Sao Paulo (FAPESP) [2011/21357-9]
- FAPESP [2035/04206-6]
- National Research Foundation of Korea grant - Korean government (Ministry of Education, Science, and Technology) [2012-0005150]
- Grants-in-Aid for Scientific Research [23591724, 24791223] Funding Source: KAKEN
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [11/21357-9] Funding Source: FAPESP
Background There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive -compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness. Aims To investigate alterations in cortical thickness and subcortical volume in OCD. Method In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. Results Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls. Conclusions Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity. Copyright and usage (C) The Royal College of Psychiatrists 2017.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据