期刊
JOURNAL OF CANCER
卷 8, 期 4, 页码 674-682出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.16901
关键词
Fibronectin; extracellular matrix; integrins; tumorigenesis; metastasis; therapy resistance
类别
资金
- Philadelphia College of Osteopathic Medicine Centers for Chronic Disorders of Aging
Fibronectin is a matrix glycoprotein which has not only been found to be over-expressed in several cancers, but has been shown to participate in several steps of tumorigenesis. The purpose of this review is to illustrate how aberrant fibronectin expression influences tumor growth, invasion, metastasis and therapy resistance. In particular, this review will focus on the interactions between cell receptor ligands and fibronectin and how this interaction influences downstream signaling events that aid tumor progression. This review will further discuss the possible implications of therapeutic drugs directed against fibronectin and/ or cellular interactions with fibronectin and will additionally discuss novel approaches by which to limit intra-and extra-tumoral fibronectin expression and the cellular events which lead to aberrant fibronectin expression. It is anticipated that these studies will set a basis for future research that will not only aid understanding of fibronectin and its prognostic significance, but will further elucidate novel targets for therapeutics.
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