期刊
JOURNAL OF CANCER
卷 8, 期 12, 页码 2319-2327出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.19079
关键词
ABC transporters; EMT; CSCs; resistance; TFs; miRNA
类别
资金
- Natural Science Foundation of China [81273647]
- Natural Science Foundation of Fujian Province [2013J01365]
- Young and middle-aged talent training project in fujian provincial health system [2015-ZQN-ZD-2]
- National health-education joint research project [WKJ-FJ-19]
Epithelial-mesenchymal transition (EMT) can directly contribute to some malignant phenotypes of tumor cells including invasion, metastasis and resistance to chemotherapy. Although EMT is widely demonstrated to play a critical role in chemoresistance and metastasis, the potential signaling network between EMT and drug resistance is still unclear. The distribution of drugs in the internal and external environment of the tumor cells is tightly linked with ATP-binding cassette (ABC) transporters. Recent studies have shown that ABC transporters expression changed continuously during EMT. We believe that EMT is an important regulator of ABC transporters. In this review, we discuss how EMT regulates ABC transporters and their potential linkages. And we hope the knowledge of EMT and ABC transporters will offer more effective targets to experimental research.
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