期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 6, 期 2, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.116.005054
关键词
blacks; atherosclerotic cardiovascular disease risk; blood pressure; hypertension; population
资金
- Jackson State University [N01-HC-95170]
- University of Mississippi Medical Center [N01-HC-95171]
- Tougaloo College [N01-HC-95172]
- National Heart, Lung, and Blood Institute [HHSN268201300046C, HHSN 268201300047C, HHSN268201300048C, HHSN268201300049C, HHSN268201300050C]
- National Institute on Minority Health and Health Disparities
- NIH from the National Heart, Lung, and Blood Institute [R01 HL117323, K24-HL125704]
- National Institute of Health, Bethesda, MD
- NIH from the National Center for Advancing Translational Sciences, Bethesda, MD [5KL2TR001065]
Background-Clinical guidelines recommend using predicted atherosclerotic cardiovascular disease (ASCVD) risk to inform treatment decisions. The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10-year predicted ASCVD risk. Methods and Results-A prospective follow-up was done of the Jackson Heart Study, an exclusively black cohort at visit 1 (20002004) and visit 3 (2009-2012). Analyses included 1115 black participants without high 10-year predicted ASCVD risk (<7.5%), hypertension, diabetes mellitus, or ASCVD at visit 1. We used the Pooled Cohort equations to calculate the incidence of high (>= 7.5%) 10-year predicted ASCVD risk at visit 3. We recalculated the percentage with high 10-year predicted ASCVD risk at visit 3 assuming each risk factor (age, systolic blood pressure, antihypertensive medication use, diabetes mellitus, smoking, total and high-density lipoprotein cholesterol), one at a time, did not change from visit 1. The mean age at visit 1 was 45.2 +/- 9.5 years. Overall, 30.9% (95% CI 28.3-33.4%) of participants developed high 10-year predicted ASCVD risk. Aging accounted for 59.7% (95% CI 54.2-65.1%) of the development of high 10-year predicted ASCVD risk compared with 32.8% (95% CI 27.0-38.2%) for increases in systolic blood pressure or antihypertensive medication initiation and 12.8% (95% CI 9.6-16.5%) for incident diabetes mellitus. Among participants <50 years, the contribution of increases in systolic blood pressure or antihypertensive medication initiation was similar to aging. Conclusions-Increases in systolic blood pressure and antihypertensive medication initiation are major contributors to the development of high 10-year predicted ASCVD risk in blacks, particularly among younger adults.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据