期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 6, 期 5, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.116.005316
关键词
antidepressants; cohort study; deep vein thrombosis; depression; pulmonary embolism
资金
- Cancer Research UK
- UK Medical Research Council
- Lifeblood
- MRC [MR/K02700X/1] Funding Source: UKRI
- Cancer Research UK [16491] Funding Source: researchfish
- Medical Research Council [MR/K02700X/1] Funding Source: researchfish
Background-Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and with use of antidepressant drugs. We explored these associations in a large prospective study of UK women. Methods and Results-The Million Women Study recruited 1.3 million women through the National Health Service Breast Screening Programme in England and Scotland. Three years after recruitment, women were sent a second questionnaire that enquired about depression and regular use of medications in the previous 4 weeks. The present analysis included those who responded and did not have prior VTE, cancer, or recent surgery. Follow-up for VTE was through linkage to routinely collected National Health Service statistics. Cox regression analyses yielded adjusted hazard ratios and 95% CIs. A total of 734 092 women (mean age 59.9 years) were included in the analysis; 6.9% reported use of antidepressants, 2.7% reported use of other psychotropic drugs, and 1.8% reported being treated for depression or anxiety but not use of psychotropic drugs. During follow-up for an average of 7.3 years, 3922 women were hospitalized for and/or died from VTE. Women who reported antidepressant use had a significantly higher risk of VTE than women who reported neither depression nor use of psychotropic drugs (hazard ratio, 1.39; 95% CI, 1.23-1.56). VTE risk was not significantly increased in women who reported being treated for depression or anxiety but no use of antidepressants or other psychotropic drugs (hazard ratio, 1.19; 95% CI, 0.95-1.49). Conclusions-Use of antidepressants is common in UK women and is associated with an increased risk of VTE.
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