期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 67, 期 4, 页码 247-257出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2017.1320661
关键词
Adipose-derived mesenchymal stem cells; biodegradation; gelatin grafting; poly(L-lactic acid); polyethylenimine hyperbranched
In this study, modification of poly(L-lactic acid) (PLLA) electrospun nanofibrous scaffolds blending with polyethylenimine (PEI) in different blend ratios was performed. The sample with 85: 15 blend ratio revealed most promising results, and was selected for further modification with gelatin. It was found that the presence of PEI could enhanced porosity, mechanical properties, surface/bulk hydrophilicity and also gelatin grafting density about five times with positive effect on cell behavior. The results indicated that the limitations of PLLA electrospun nanofibers for potential application as a functional tissue engineering scaffold (i.e., poor cell adhesion and necrosis of host tissues as a result of providing acidic environment while degradation) could be overcome through blending with PEI and grafting with gelatin. [GRAPHICS] .
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