期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 66, 期 -, 页码 120-129出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2016.06.006
关键词
Leptin; Innate immunity; Adaptive immunity; Non-mammalian vertebrates
资金
- Fondazione Italiana Sclerosi Multipla [2012/R/11, 2014/R/21]
- Italian Space Agency [2014-033-R.O.]
- European Foundation for the Study of Diabetes/Juvenile Diabetes Research Foundation (EFSD/JDRF)/Lilly Programme
- Ministero della Salute Grant [GR-2010-2315414]
- TRIDEO-AIRC [17447]
- Juvenile Diabetes Research Foundation [1-PNF-2015-115-5-B]
- European Foundation for the Study of Diabetes [JDRF Lilly 2015_4] Funding Source: researchfish
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. Initially described as an anti-obesity hormone, leptin has subsequently been shown to exert pleiotropic effects, being also able to influence haematopoiesis, thermogenesis, reproduction, angiogenesis, and more importantly immune homeostasis. As a cytokine, leptin can affect both innate and adaptive immunity, by inducing a pro-inflammatory response and thus playing a key role in the regulation of the pathogenesis of several autoimmune/inflammatory diseases. In this review, we discuss the most recent advances on the role of leptin as immune-modulator in mammals and we also provide an overview on its main functions in non-mammalian vertebrates. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据