期刊
CELL COMMUNICATION AND SIGNALING
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12964-016-0160-z
关键词
Immunotherapy; PD-1; PD-L1; T cell exhaustion; Cancer
类别
资金
- Austrian science fund FWF [P24619, P28201]
- LIMCR-SCRI
- province of Salzburg
- city of Salzburg
- Austrian Science Fund (FWF) [P 28201, P 24619] Funding Source: researchfish
- Austrian Science Fund (FWF) [P24619, P28201] Funding Source: Austrian Science Fund (FWF)
The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoimmunity and immunopathology. One of the mechanisms that have evolved to prevent destruction by the immune system, is to functionally silence effector T cells, termed T cell exhaustion, which is also exploited by viruses and cancers for immune escape In this review, we discuss some of the phenotypic markers associated with T cell exhaustion and we summarize current strategies to reinvigorate exhausted T cells by blocking these surface marker using monoclonal antibodies.
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